Friday, October 19, 2012

Cellulitis: diagnosis and management.


Cellulitis: diagnosis and management.


Mar 2011

Source

Columbia University College of Physicians and Surgeons, New York, NY, USA.

Abstract


Cellulitis is an acute infection of the dermal and subcutaneous layers of the skin, often occurring after a local skin trauma. It is a common diagnosis in both inpatient and outpatient dermatology, as well as in the primary care setting. Cellulitis classically presents with erythema, swelling, warmth, and tenderness over the affected area. There are many other dermatologic diseases, which can present with similar findings, highlighting the need to consider a broad differential diagnosis. Some of the most common mimics of cellulitis include venous stasis dermatitis, contact dermatitis, deep vein thrombosis, and panniculitis. History, local characteristics of the affected area, systemic signs, laboratory tests, and, in some cases, skin biopsy can be helpful in confirming the correct diagnosis. Most patients can be treated as an outpatient with oral antibiotics, with dicloxacillin or cephalexin being the oral therapy of choice when methicillin-resistant Staphylococcus aureus is not a concern.

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Sunday, October 11, 2009

How Cracked heels can let killer bacteria invade your body

How Cracked heels can let killer bacteria
invade your body


Last updated at 10:20 AM on 06th October

One night as Chris Banting was undressing for bed, he was surprised

when his wife Helen pointed out to him that the back of his right calf was

a worrying scarlet colour.


'It was strange because I wasn't in any discomfort at all,' says Chris, 62.


'If you have an infection, you think you'd be in pain or running a temperature,

but I felt fine.'


It was November 2007 and the busiest time of the year in his job as a charity

fundraising manager, but he decided it was something he should get checked

out.


In fact, Chris was suffering from cellulitis - a serious bacterial infection of the

skin.


Left untreated, the bacteria can spread through the body and cause potentially

fatal blood poisoning or an infection of the muscle, bone or heart valve.


Around 70,000 people are hospitalised with it every year.


Cellulitis - not to be confused with cellulite - affects the deep layer of skin

known as the dermis, and sometimes the layer of fat and soft tissues beneath.


Initially, it causes the skin to become sore, red and swollen.


Though it commonly affects the lower legs, it can occur on any part of the body.


Dr Nick Lowe, consultant dermatologist and spokesperson for the

British Skin Foundation, explains that we all have bacteria living on our skin.


Usually this doesn't cause any harm, but if the skin is damaged by an ulcer, cut,

graze or insect bite, or even if it is simply cracked through conditions such as

eczema, the bacteria can get in, causing an infection.


Nail infections or ingrown toenails can also be a source.


'When this happens, the infected area becomes inflamed, tender, red and

often hot,' says Dr Lowe.


'It may also blister. The infection is usually accompanied by symptoms of feeling

generally unwell, including fever and nausea.'


Those with weakened immune systems are particularly vulnerable, as their bodies

lack the strength to fight off the infection.


Other risk factors include diabetes, as it often causes poor blood supply to the skin,

which may lead to ulcers that can serve as an entry point for bacteria.


Athlete's foot can also make you more prone to cellulitis, as this may cause the skin to

crack.


A severe case of cracked heels could make you more vulnerable, too. As can

lymphedema - a condition that causes swelling in a part of the body because of fluid

build-up under the skin.


However, cellulitis can occur without a wound, when bacteria enters through

the lymphatic system.


The speed at which the symptoms manifest themselves depends on the

health of the infected patient.


'In a very healthy person, symptoms may take up to a week to appear,' says Dr Lowe.


'But in the elderly or those with weakened immune systems, symptoms can come

on rapidly, in just a day or two.


'This is why prompt diagnosis-and treatment with antibiotics is vital, before the

infection spreads.'


When Chris Banting discovered the angry rash on his leg, he made an appointment

at an out- of-hours clinic near his home in .


The doctor diagnosed cellulitis and gave Chris a prescription for antibiotics.


'He told me the most likely point of entry for the bacteria that had caused

my cellulitis had been cracks on the soles of my feet,' says Chris.


'I'd had athlete's foot since I was a teenager, and on top of a recent attack, which I'd

been treating with an anti-fungal cream, had developed a secondary fungal

infection that had caused the cracks.


'I'd heard cellulitis can potentially kill you, but that didn't even enter my head

then. My wife had been through the same thing, and although she'd spent a week

in hospital, she'd been cured, so I thought I'd take the antibiotics and I'd be fine.'


Generally, a course of antibiotics is enough to clear up the infection, but despite

the prompt diagnosis, his symptoms got progressively worse.


Just two days later, he had developed a huge blister on his right calf, around

one-and-a-half inches deep and the diameter of a grapefruit.


'I'd never seen anything like it,' says Chris. 'It seemed to have come out of

nowhere.


'Worse still, the stuff leaking out of it looked like some kind of machine oil.

It was revolting!'


Chris went straight to his GP, who took one look at his leg and told him he

needed to go to hospital.


'She explained the infection had gone beyond the stage when oral

antibiotics would help, and that I'd need to be admitted for intravenous

antibiotics,' he says.


'It was all rather dramatic and happened very quickly.'


Chris was admitted to the Bristol Royal Infirmary.


'One of the first things the doctors did was to draw on my leg with a

marker pen around the outline of the infected skin, so they could keep

track of whether it was spreading or not,' says Chris.


'It would seem it can spread rapidly in some instances - but luckily mine

stayed roughly the same.'


Thankfully, within a couple of days, Chris's infection began to dwindle

(his athlete's foot was also effectively treated).


He remained in hospital for a week and was then released to the care

of his GP surgery, where he went daily for ten days to have his dressings

changed.


Now the only lasting sign he ever suffered from cellulitis is a patch of

discoloured skin extending from behind the knee to the ankle bone.


Though he's recovered, Chris could well suffer a recurrence. Around

one-third of people develop cellulitis again within three years.


'Once you've had cellulitis, you're more likely to get it again - and in

the same area,' says Dr Lowe.


'This is because the infection can damage the lymph channels in the

area, so they become less efficient at filtering out germs.


Therefore, you need to be scrupulous about skin cleansing and keeping

your skin moisturised, to prevent it drying out and cracking.'


Meanwhile, Chris is thankful for the first-class treatment he received -

and to his wife for spotting the symptoms in the first place.


'If she hadn't, goodness knows what could have happened,' he says.


Mail Online


For additional information:


Cellulitis


Complications of Cellulitis and Lymphangitis


Prevention of Cellulitis

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Monday, October 08, 2007

Clinical Presentation of Cellulitis (erysipelas)

Clinical Presentation of Cellulitis (erysipelas)
Posted by EditorsChoice

Sunday, 07 October 2007


Diagnosis Hallmarks Distribution: no characteristic pattern Sudden onset of a large red plaque Pain and tenderness Rapid response to antibiotic therapy

Clinical Presentation

Cellulitis occurs as a tender, edematous, bright red plaque 5 to 20 cm in diameter. Generally, only a single lesion is present. A thin red line progressing proximally from the lesion (lymphangitis) is seen in about 20% of patients The initial lesion of cellulitis appears suddenly. Centrifugal growth of the lesion is rapid during the first 24 hours but occurs more slowly thereafter. Cellulitis is quite tender, but it is less painful than furunculosis, and fluctuant areas never develop. Fever, malaise, and regional lymphadenopathy may or may not be present.

Differentiation of cellulitis from an acute urticarial plaque such as occurs following bee stings is sometimes difficult, but the course of events over the succeeding 24 hours generally allows for appropriate identification.

The diagnosis of cellulitis is made on a clinical basis. It is theoretically possible to culture the lesion by way of injection, and subsequent aspiration, of sterile saline, but most clinicians do not find this helpful or necessary.

Course and Prognosis

Most instances of cellulitis resolve spontaneously over 10 to 20 days. Unfortunately, in debilitated or otherwise immunocompromised patients there may be progressive spread, and systemic infection may develop. The process is particularly troublesome when it occurs in patients taking systemic steroids, since not only is resistance reduced but the signs and symptoms of the infection may be greatly masked by the anti-inflammatory action of the steroids.

Special attention should be given to cellulitis of the central face, since, if it is left untreated, there is a significant risk of extension to the cavernous sinus.

Cellulitis is not usually recurrent. In patients with chronic lymphedema, however, there is a tendency both for the development of multiple lesions and for the occurrence of repeated episodes. The presence of hypesthesia, anesthesia, or blister formation (especially if the fluid is yellow or hemorrhagic) over an area of cellulitis should alert the clinician to the possible presence of underlying necrotizing fasciitis.

Pathogenesis

Cellulitis is a nonfollicular, mid to deep dermal infection caused by Staphylococcus aureus or Streptococcal pyogenes. Clinical signs indicating which of the two organisms is responsible are unreliable, but lymphangitis is more commonly found in staphylococcal infection. Fever, on the other hand, is more often seen in streptococcal infection. Trauma to the skin predisposes to the development of cellulitis, but occurrence ill the absence of trauma is common. Patients with chronic lymphedema seem particularly susceptible to the development of cellulitis.

Therapy

Systemic antibiotics, the treatment of furunculosis should be administered to all patients with cellulitis. It is not necessary to decide whether the problem is staphylococcal or streptococcal before initiating therapy, and in fact, culture is usually not possible even with saline injection and aspiration . Incision and irainage are never carried out. Hot packs or hot soaks are often recommended, but there is little evidence that this approach speeds resolution.

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