Prospective evaluation of the management of moderate to severe cellulitis with parenteral antibiotics at a paediatric day treatment centre.

Prospective evaluation of the management of moderate to severe cellulitis with parenteral antibiotics at a paediatric day treatment centre.

J Paediatr Child Health. 2007 Oct 18

Gouin S, Chevalier I, Gauthier M, Lamarre V.
Division of Emergency Medicine, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montréal, Québec, Canada.

Aim:

To assess the clinical outcome of patients with moderate to severe cellulitis managed at a paediatric day treatment centre (DTC).

Methods:

Prospective observational study of all patients (3 months to 18 years) with a presumed diagnosis of moderate to severe cellulitis made in a university-affiliated paediatric emergency department (ED) (September 2003 to September 2005). Patients treated at the DTC were given ceftriaxone or clindamycin.

Results:

During the study period, a presumed diagnosis of moderate to severe cellulitis was made in 224 patients in the ED. Ninety-two patients were treated at the DTC (41%). The cellulitis had a median width of 7.0 cm (range: 1.0-50.0 cm) and a median length of 6.5 cm (range: 1.0-40.0 cm). Blood cultures were performed in 95.7%; one was positive for Staphylococcus aureus. After a mean of 2.5 days of intravenous therapy (first injection in the ED and a mean of 1.5 days at the DTC), 73 patients (79.3%) were successfully discharged from the DTC and switched to an oral agent. For these patients no relapse occurred. Nineteen patients (20.7%) required inpatient admission for further therapy. No patient was diagnosed with necrotizing fasciitis in the course of therapy. Seventy-eight satisfaction questionnaires were handed in and revealed very good to excellent parental satisfaction with treatment at the DTC in 94.8%.

Conclusion:

Treatment with parenteral antibiotic at a DTC is a viable alternative to hospitalisation for moderate to severe cellulitis in children.

Blackwell

Clinical Presentation of Cellulitis (erysipelas)

Clinical Presentation of Cellulitis (erysipelas)
Posted by EditorsChoice

Sunday, 07 October 2007

Diagnosis Hallmarks Distribution: no characteristic pattern Sudden onset of a large red plaque Pain and tenderness Rapid response to antibiotic therapy

Clinical Presentation

Cellulitis occurs as a tender, edematous, bright red plaque 5 to 20 cm in diameter. Generally, only a single lesion is present. A thin red line progressing proximally from the lesion (lymphangitis) is seen in about 20% of patients The initial lesion of cellulitis appears suddenly. Centrifugal growth of the lesion is rapid during the first 24 hours but occurs more slowly thereafter. Cellulitis is quite tender, but it is less painful than furunculosis, and fluctuant areas never develop. Fever, malaise, and regional lymphadenopathy may or may not be present.

Differentiation of cellulitis from an acute urticarial plaque such as occurs following bee stings is sometimes difficult, but the course of events over the succeeding 24 hours generally allows for appropriate identification.

The diagnosis of cellulitis is made on a clinical basis. It is theoretically possible to culture the lesion by way of injection, and subsequent aspiration, of sterile saline, but most clinicians do not find this helpful or necessary.

Course and Prognosis

Most instances of cellulitis resolve spontaneously over 10 to 20 days. Unfortunately, in debilitated or otherwise immunocompromised patients there may be progressive spread, and systemic infection may develop. The process is particularly troublesome when it occurs in patients taking systemic steroids, since not only is resistance reduced but the signs and symptoms of the infection may be greatly masked by the anti-inflammatory action of the steroids.

Special attention should be given to cellulitis of the central face, since, if it is left untreated, there is a significant risk of extension to the cavernous sinus.

Cellulitis is not usually recurrent. In patients with chronic lymphedema, however, there is a tendency both for the development of multiple lesions and for the occurrence of repeated episodes. The presence of hypesthesia, anesthesia, or blister formation (especially if the fluid is yellow or hemorrhagic) over an area of cellulitis should alert the clinician to the possible presence of underlying necrotizing fasciitis.

Pathogenesis

Cellulitis is a nonfollicular, mid to deep dermal infection caused by Staphylococcus aureus or Streptococcal pyogenes. Clinical signs indicating which of the two organisms is responsible are unreliable, but lymphangitis is more commonly found in staphylococcal infection. Fever, on the other hand, is more often seen in streptococcal infection. Trauma to the skin predisposes to the development of cellulitis, but occurrence ill the absence of trauma is common. Patients with chronic lymphedema seem particularly susceptible to the development of cellulitis.

Therapy

Systemic antibiotics, the treatment of furunculosis should be administered to all patients with cellulitis. It is not necessary to decide whether the problem is staphylococcal or streptococcal before initiating therapy, and in fact, culture is usually not possible even with saline injection and aspiration . Incision and irainage are never carried out. Hot packs or hot soaks are often recommended, but there is little evidence that this approach speeds resolution.

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